Comparative Study on Efficacy of Aloe Vera Leaf and Gel Extracts against Tinea Corporis and Malasezia Furfur

Issue (Month/Year): (11 – 2020)
Publication Date: 30-11-2020
Subject: Environmental Microbiology
Author’s Details: Ogbeba, J.
Co-author’s Details: Adeosun, F.F, Iruolaje, F. O, Yohanna, L. Z..

Abstract 

This study was carried out to determine the phytochemical constituents and comparative antifungal effects of the leaf and gel of Aloe vera (Aloe barbadensis) against some dermatophytes. The antifungal efficacy of Aloe barbadensis leaf and gel extract was tested against Tinea corporis and Malassezia furfur using agar well diffusion assays. The phytochemical screening revealed the presence of saponin, alkaloid, tannin, flavonoid and glycoside in both leaf and gel extracts of Aloe barbadensis, while steroid was absent in both extracts. Antifungal test was carried out for both leaf and gel extract at 100% concentration. It was observed that the Aloe vera gel extract (GE) showed high activity against Tinea corporis and Malassezia furfur with zones of inhibition of 10.5±0.2mm and 10.1±0.2mm respectively, while the leaf extract (LE) had zones of 8.7±0.2mm and 6.4±0.1mm for both Malassezia furfur and Tinea corporis respectively. The positive control (Zinc pyrithione) had slightly higher antifungal effect (10.9±0.5mm) in comparison with that of gel extract (GE) against Tinea corporis (10.5±0.2mm) and Malassezia furfur (10.1±0.2mm). The MIC of gel extract against both Tinea corporis and Malassezia furfur was 25%, while the leaf extract had 25% for Malassezia furfur and 50% for Tinea corporis. The result obtained from the study revealed that both leaf and gel extracts of Aloe barbadensis have high antifungal effect against the test organisms and could be potent in the production of alternative new antifungal agents.

 

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